QB
RB
RB2
WR
WR2
TE
FLEX
EDGE
EDGE2
DT
LB
CB
CB2
S
Lead slots carry more of the score than support slots. If two players can fill similar roles, give the better player the higher-value slot.
QBYour highest-leverage single decision. Passing is the main value, but QB rushing yards and rushing TDs count too.
RB / RB2 / FLEXRB is the feature back. RB2 gives about 31% of RB's rushing impact, and a running back in FLEX gives about 15%. RB receiving yards and receiving TDs are folded into his value.
WR / WR2 / FLEXWR2 gives about 67% of WR's receiving impact. A WR or TE in FLEX gives about 18% of the receiving impact he would give as your WR, so FLEX is useful but not a lead role.
TETE gives about 38% of WR's receiving impact. A great TE should usually fill TE before FLEX.
EDGE / EDGE2EDGE2 gives about 67% of EDGE's pass-rush impact. Put your best pressure player at EDGE.
CB / CB2 / SCB2 and S each give about 75% of CB's coverage impact. CB is the lead cover slot, but all three are important.
DT / LBDT drives defensive-line value. LB mostly protects run defense, so avoid parking your best pass-rusher there unless you have to.
Quick rule: lead slots get your stars. Support slots are still useful, but they should catch the next-best fit.